English: St. Jerome (ca. 347-420), one of the four Latin Fathers of the Church (along with Sts. Augustine, Ambrose, and Gregory the Great), is particularly famous for translating the Bible into Latin, known as the Vulgate Bible. The saint spent four years in the Syrian desert as a hermit, mortifying his flesh and elevating his spirit through study. The subject has given Pinturicchio the opportunity to depict a monumental, rocky landscape, while the lizard and the scorpion call attention to the desolation of the scene. The open book contains a passage from a letter attributed to St. Augustine in which Jerome is compared to St. John the Baptist, another saint who lived in the wilderness.